In her chapter of the newly published book Neuroscience in Criminal Justice Systems: The Positive Impact of Neurojustice, Fordham Law Professor and Founding Director of the Neuroscience and Law Center Deborah Denno explores the use of neuroscientific evidence in criminal cases involving brain injury, both from external causes (e.g., car accidents or gunshot wounds) and internal causes (e.g., dementia or alcohol-induced brain damage). The chapter titled, “The Neuroscience of Brain Injury in Criminal Cases: An International Scope,” compares Professor Denno’s own research in the United States with similar studies in five other countries, none of which use the death penalty (Australia, Canada, England and Wales, and The Netherlands). She particularly focuses on the hypothesized “double-edged sword effect,” in which neuroscientific evidence of brain injury may be seen as both mitigating and aggravating in criminal cases.
Yet, the results of my twelve-decade U.S. Neuroscience Study and the empirical research conducted in six countries show that the double-edged sword concept does not fully reflect reality; instead, it is an outdated framework fueled by potentially deleterious misunderstandings.
In Professor Denno’s own study, she examined the cases of 7,776 defendants — nearly half of whom faced the death penalty — involving brain injuries from 1900 – 2020 and shared four key findings. First, 7.73% of cases raised information about a defendant’s brain injury, perhaps due to the importance of other factors in the individual’s case. Second, cases with mention of brain injury increased over time from 4 – 5% during 1900 – 1980 to 14% in 2020. Third, there was no difference in the state’s argument of future dangerousness when comparing brain injury cases and non-brain injury cases; in fact, a claim of future dangerousness related to neuroscience evidence only occurred 4% of the time. And finally, of the cases in which a future dangerousness issue was raised in brain injury cases (26), 65% of cases explicitly related the risk to a defendants’ brain injury, whereas 35% associated the future risk with another neuroscientific condition the defendant had, not with their brain injury.
While Professor Denno did not find a double-edged sword effect in her study, she notes that this lack of finding does not confirm the absence of such an effect, providing two capital case examples to illustrate the potential workings of such an effect in the U.S. criminal legal system. Professor Denno notes that in People v. Buss the prosecution highlighted the “intractability of a defendant’s brain injury,” whereas this same argument was found to be unsuccessful in United States v. Runyon. While the prosecution tried to argue that evidence of Mr. Runyon’s brain injury was “weak” and “double-edged,” the U.S. Court of Appeal for the Fourth Circuit reversed the lower court’s dismissal of the ineffective assistance of counsel claim, agreeing that defense counsel should have introduced key evidence of brain injury as a mitigator. In general, Professor Denno explains that U.S. courts have consistently found that examining defendant’s “cognitive or intellectual deficiencies” is a key part of mitigation, particularly in capital cases. Although the development and presentation of mitigation is a priority, Professor Denno notes that the potential rehabilitation of a defendant is “far less, if ever, a factor with respect to neuroscientific evidence because the death penalty or the prospect of a harsh sentence looms.” She explains that “rehabilitation is not considered relevant in the way it could be in non-death penalty countries where sentences are far less severe.”
Although the international studies varied methodologically (e.g., types of crimes, timespan), they all relied on data from legal databases to investigate the use of neuroscientific evidence, such as neuroimaging tests (e.g., MRI), non-neuroimaging tests (e.g.,psychometric tests), and expert testimony in criminal cases. Professor Denno found there to be a continuum for a double-edged sword effect, with Slovenia on one end and England and Wales on the other. Slovenia was an outlier in having no double-edged sword effect; there was an emphasis on mitigation and rehabilitation in their criminal legal system, with this reflected in alternative treatment options. Although two Australian studies found a double-edged sword effect, the 2023 study focusing on sentencing cases found that neuroscientific evidence more likely led to leniency in cases (85%). The Netherlands study noted the presence of a double-edged sword effect particularly in brain injury cases with a high risk of severe violence, but sentencing mitigation was still possible due to their criminal legal system’s emphasis on providing defendants opportunities to improve. The Canadian study found a double-edged sword effect, especially given the presumed permanency of brain injuries and the lack of appropriate treatment alternatives in the system. Although the England and Wales study did not explicitly address the double-edged sword effect, the study explains how the prosecution and defense both use neuroscience evidence; Professor Denno found them to fall on the furthest extreme of the continuum, as the prosecution is more likely than the defense to introduce neuroscientific evidence and both nation’s systems have limited rehabilitation options. “This chapter’s studies show that the risk of the double-edged sword effect is too low for defense attorneys to justify withholding neuroscientific evidence concerning a defendant’s brain injury, even when the injury appears to be permanent or untreatable,” concluded Professor Denno.
This chapter’s studies show that the risk of the double-edged sword effect is too low for defense attorneys to justify withholding neuroscientific evidence concerning a defendant’s brain injury, even when the injury appears to be permanent or untreatable.
Deborah W. Denno, The Neuroscience of Brain Injury in Criminal Cases: An International Scope, in NEUROSCIENCE IN CRIMINAL JUSTICE SYSTEMS: THE
POSITIVE IMPACT OF NEUROJUSTICE. London: Routledge Press 24 – 44 (Hannah Wishart & Colleen M. Berryessa, eds. 2026)